Anne is at a crossroads in her life. Long married to a successful, driven but inattentive movie producer, she unexpectedly finds herself taking a car trip from Cannes to Paris with a business associate of her husband. What should be a seven-hour drive turns into a carefree two-day adventure replete with diversions involving picturesque sights, fine food and wine, humor, wisdom and romance, reawakening Anne's senses and giving her a new lust for life.

This movie is a portrait of one of the most important and tragic moments in American history, seen through the eyes of the iconic First Lady, then Jacqueline Kennedy (Natalie Portman). Jackie places us in her world during the days immediately following her husband's assassination. Known for her extraordinary dignity and poise, here we see a portrait of the First Lady as she fights to establish her husband's legacy and the world of "Camelot" that she created and loved so well.